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1 row where hash_id = "b2f26b5a807cff86"
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| rowid ▼ | hash_id | code | kind | repeat | desc | narrative |
|---|---|---|---|---|---|---|
| 49 | b2f26b5a807cff86 | 2.31(c)(7) | 0 | Institutional Animal Care and Use Committee (IACUC). | Pertaining to IACUC approved Protocol 200794: The proposal for animal use was reviewed along with the medical records for 13 rabbits on the study. The following instances of the laboratory staff implementing significant changes in an ongoing activity without prior review and approval by the IACUC and instances of the laboratory staff not following the approved protocol were identified. The deviations with the IACUC approved protocol were identified by the IACUC during the November 2023 semi-annual facility inspection. 1. According to the research facility’s IACUC Acclimation Policy that investigators are to follow for all IACUC approved protocols, the acclimation period for all non-rodents is a minimum of 7 days. Review of facility records for the 6 rabbits delivered on 11/16/23 revealed that the 6 rabbits underwent a procedure requiring anesthesia on 11/17/23 (1 day of acclimation) and 1 rabbit delivered on 12/7/23 underwent a procedure requiring anesthesia on 12/12/23 (5 days of acclimation). Shortening of the acclimation period is a significant change regarding the use of animals in an ongoing activity that was not reviewed or approved by the IACUC committee. 2. Protocol states that two injections of the study compound will be administered to the rabbits. The first injection will be administered on study day 0 and the second injection of the study compound will be administered three days later on study day 3. Review of the medical record of rabbit #448 revealed that the study day 0 injection was administered on 12/29/23 and the second injection was administered 6 days later on 1/4/24. Doubling the time interval between study compound injections is a significant change regarding the use of animals in an ongoing activity that was not reviewed or approved by the IACUC committee. 3. Protocol states that the intra-articular injection will be performed under general anesthesia (acepromazine followed by inhalant agent). There was no documentation noted in the review of the medical records of 10 animals that the inhal… |
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CREATE TABLE "citations" ( [rowid] INTEGER PRIMARY KEY, [hash_id] TEXT REFERENCES [inspections]([hash_id]), [code] TEXT, [kind] TEXT, [repeat] INTEGER, [desc] TEXT, [narrative] TEXT );