citation_inspection: 64

Review of IACUC approved protocol #9-075: The written narrative description of the methods and sources used to determine that alternatives were not available to the procedures that may cause more than momentary pain or distress to the animals that are included in the proposal, refers to the use of a database search to determine there are no suitable alternatives. However, none of the terms used in the database search strategy pertained to the specific surgical procedures contained in the proposal (such as laparotomy, thoracotomy). Per this Section, whenever a proposal for animal use contains procedures that may cause more than momentary pain or distress to the animals, the IACUC shall determine that (1) the principal investigator has considered alternatives to those procedures and (2) that the written narrative description of the methods and sources used by the principal investigator to determine that alternatives were not available adequately addresses all of the potentially painful procedures contained in the proposal. These requirements ensure that all procedures contained in the protocol minimize discomfort, distress, and pain to the animals. The IACUC needs to address this item identified for this protocol. Correct by 1/16/24. This inspection and exit briefing were conducted with facility representatives. *END OF REPORT* n